Entity Address, City or Town
Entity Address, City or Town
Deferred tax liabilities:
Deferred Tax Liabilities, Net [Abstract]
Warrants
Warrants And Rights Note Disclosure [Text Block]
The entire disclosure for warrants and rights.
Original Term Loan 2016
Original Term Loan2016 [Member]
This member stands for 2016 Original Term Loan.
Debt Instrument Prepayment Occurring Prior To First Anniversary Of First Amendment Closing Date [Member]
Debt instrument prepayment occurring prior to first anniversary of first amendment closing date.
Prepayment Occurs Prior to First Anniversary of First Amendment Closing Date
Schedule of Income Tax Rate Reconciliation
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Fair Value Disclosures [Abstract]
Accounting Standards Update and Change in Accounting Principle [Table]
2016 Shelf Registration
Two Thousand Sixteen Shelf Registration [Member]
Two thousand sixteen shelf registration.
Earnings Per Share [Abstract]
Level 1
Fair Value, Inputs, Level 1 [Member]
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Tax Year 2018
Tax Year 2018 [Member]
Fair value of common stock
Common Stock Fair Value
Fair value of issued nonredeemable common stock (or common stock redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable common shares, par value and other disclosure concepts are in another section within stockholders' equity.
Share issued, value
Proceeds from issuance of common stock, gross
Stock Issued During Period, Value, New Issues
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Weighted average contractual term
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
License Agreement
License Agreement Terms [Member]
Current Loan amount
Line of credit
Long-Term Line of Credit
Long-Term Line of Credit, Total
Amendment Flag
Amendment Flag
Inventory [Line Items]
Long-Term Debt, Maturity, Year Four
2025
Subsequent Event Type [Domain]
Research and Development [Abstract]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Accumulated Amortization
Accumulated Amortization
Finite-Lived Intangible Assets, Accumulated Amortization
2022 warrants
Term Loan Two Thousand and Twenty Two Warrants [Member]
Term loan two thousand and twenty two warrants.
Goodwill
Goodwill
Goodwill, Ending Balance
Goodwill, Beginning Balance
Goodwill, Total
Right-of-use asset - operating lease
Operating Lease, Right-of-Use Asset
Schedule of Net Book Value of our Intangible Asset
Schedule of Finite-Lived Intangible Assets [Table Text Block]
Net state operating loss carryforward
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
Less imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Basic and Diluted Net Loss per Common Share
Earnings Per Share, Policy [Policy Text Block]
Percentage of discount rate intangible asset measurement input
Percentage of Discount Rate Intangible Asset Measurement Input
Percentage of discount rate intangible asset measurement input.
Inventory, Current [Table]
Statement [Table]
Statement [Table]
Operating lease liability, long-term
Operating Lease, Liability, Noncurrent
Dr. Tabuteau
Chief Executive Officer [Member]
Lease Liability
Deferred Tax Assets Leasing Arrangements
Deferred tax assets leasing arrangements.
Common stock sales agreement, authorized amount
Common Stock Sales Agreement Authorized Amount
The authorized amount under a common stock sales agreement.
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in accounting principle, accounting standards update, immaterial effect
Total
Inventory Current and Noncurrent
Inventory current and noncurrent.
Number of operating segments
Number of Operating Segments
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Business Acquisition [Axis]
Auditor Firm ID
2019 Warrants
Warrants2019 [Member]
Information pertaining to 2019 warrants.
Weighted average grant date fair value, Outstanding, beginning balance
Weighted average grant date fair value, Outstanding, ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted average grant date fair value, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Debt Instruments Maturity Month And Year
Debt instruments maturity, month and year.
Debt instrument maturity, month and year
Inventory
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Inventory
2020 Warrants
Term Loan2020 Tranche One [Member]
Represents about term loan tranche one.
Line Of Credit Facility [Line Items]
Line of Credit Facility [Line Items]
Business Combination
Business Combination Disclosure [Text Block]
Long term debt increase decrease threshold amount
Long Term Debt Increase Decrease Threshold Amount
Long term debt increase decrease threshold amount.
Product and Service
Product and Service [Axis]
Amended Term Loan 2016
First Amendment Term Loan [Member]
This member stands for first amended term loan.
Debt Issuance Costs
Debt, Policy [Policy Text Block]
Contingent consideration
Business Combination, Contingent Consideration, Liability
Business Combination, Contingent Consideration, Liability, Total
Intangible assets, Estimated period of benefit
Remaining Weighted-Average Useful Life
Finite-Lived Intangible Asset, Useful Life
Employee-related Liabilities, Current, Total
Accrued compensation
Employee-related Liabilities, Current
Stock Options
Stock Options
Share-Based Payment Arrangement, Option [Member]
Debt Instrument Prepayment Occurs On Or After Second Anniversary And Prior To Third Anniversary Of First Amendment Closing Date [Member]
Debt instrument prepayment occurs on or after second anniversary and prior to third anniversary of first amendment closing date.
Prepayment Occurs on or After Second Anniversary and Prior to Third Anniversary of First Amendment Closing Date
Operating lease, remaining lease term
Operating Lease, Weighted Average Remaining Lease Term
Total liabilities and stockholders’ equity
Liabilities and Equity
Tax Period
Tax Period [Axis]
Inventory
Inventory, Policy [Policy Text Block]
Lease Asset
Deferred Tax Liabilities, Leasing Arrangements
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Plan Name
Plan Name [Domain]
Term loan2022 tranche one
Term Loan2022 Tranche One [Member]
Term loan2022 tranche one member
Line of Credit Facility, Lender [Domain]
Cost, Product and Service [Extensible Enumeration]
Non-current inventory and other assets
Other Inventory, Noncurrent
Supplemental disclosures of non-cash financing activity:
Other Noncash Investing and Financing Items [Abstract]
Raw materials
Inventory, Raw Materials, Gross
Term loan 2020 tranche two
Term Loan2020 Tranche Two [Member]
Represents about term loan tranche two.
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in accounting principle, accounting standards update, adopted
Discount rate
Measurement Input Discount Rate
Measurement Input, Discount Rate [Member]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Income Statement [Abstract]
Cash pay interest rate
Debt Instrument Threshold Cash Pay Interest Rate
Effective cash pay interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium.
Ex-U.S. Markets
Non-US [Member]
Tranche Two Sub Tranche One
Tranche Two Sub Tranche One [Member]
Tranche two sub tranche one.
Nature of Business and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Goodwill [Abstract]
Goodwill [Abstract].
Final payment fee
Extinguishment Of Debt Fee Amount
The final payment fee at extinguishment of debt.
Sale of Stock
Sale of Stock [Domain]
Contingent consideration
Contingent Consideration [Member]
Contingent consideration [Member].
Total current liabilities
Liabilities, Current
Third Amendment To Loan and Security Agreement
Third Amendment To Loan and Security Agreement [Member]
Third amendment to loan and security agreement.
Business Combination
Business Combinations Policy [Policy Text Block]
Future milestone payments
Collaboration Arrangement Future Potential Payments
The amount of future payments payable under the collaboration arrangement.
Minimum amount of market capital to be maintained
Long Term Debt Additional Drawn Covenant Minimum Market Capitalization Amount
The minimum amount of market capital to be maintained under debt instruments.
Operating Loss Carryforwards, Total
NOL carryforwards
Operating Loss Carryforwards
Lessee, Operating Lease, Liability, to be Paid, Year Three
2024
Sharebased compensation arrangement by sharebased payment award other than option lapsed intrinsic value.
Sharebased Compensation Arrangement by Sharebased Payment Award Other than Option Lapsed Intrinsic Value
Intrinsic value lapsed
Long-Term Debt, Maturity, Year Five
2026
Business Acquisition, Acquiree [Domain]
2018 Warrants
Warrants2018 [Member]
Information pertaining to 2018 warrants.
Fair Value, Recurring [Member]
Fair Value, Recurring [Member]
Accounts receivable, Allowance for credit loss
Accounts Receivable, Allowance for Credit Loss
Accounts Receivable, Allowance for Credit Loss, Ending Balance
Accounts Receivable, Allowance for Credit Loss, Beginning Balance
Accrued Expenses and Other Current Liabilities
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Income Taxes
Income Tax, Policy [Policy Text Block]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Non-cash research and development license expense
Noncash Research And Development Expense
The aggregate noncash costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Long term debt different from remaining drawn covenant minimum cash flow percentage.
Long Term Debt Different From Remaining Drawn Covenant Minimum Cash Flow Percentage
Minimum different from remaining percentage of cash flow
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Operating lease, discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Weighted average grant date fair value, Cancelled
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled Weighted Average Grant Date Fair Value
Share based compensation arrangement by share based payment award equity instruments other than options cancelled weighted average grant date fair value.
Investment, Name [Domain]
Type of Revenue [Extensible List]
Revenue, Product and Service [Extensible Enumeration]
Variable Rate
Variable Rate [Axis]
Entity Small Business
Entity Small Business
Cash at end of period
Cash at beginning of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Total
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Fair value
Fair Value Of Warrants
The fair value of outstanding warrants.
Revenue milestones
Revenue Milestones
Revenue milestones.
Intangible Asset
Intangible Assets Disclosure [Text Block]
Period of unpaid invoices amount maintain as security
Long Term Debt Additional Drawn Covenant Additional Security Unpaid Invoices Period
The period of unpaid invoices after threshold period respective amount should be keep as a security under the debt instruments.
Net operating loss carryovers and carry backs offset percentage
Tax Cuts And Jobs Act Net Operating Loss Carryovers And Carry Backs Offset Percentage
Tax cuts and jobs act net operating loss carryovers and carry backs offset percentage.
Prepayment Occurs Prior to First Anniversary of Closing Date
Debt Instrument Prepayment Occurring Prior To First Anniversary Of Closing Date [Member]
Represents the prepayment of debt occurring prior to first anniversary of closing date.
Subject To FDA Approval Of AXS Zero Five And AXS Zero Seven [Member]
Subject to FDA approval of AXS zero five and AXS zero seven.
Subject to FDA Approval of AXS 05 and AXS 07
Total current assets
Assets, Current
Aggregate intrinsic value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest [Abstract]
Common stock sales agreement, gross sales
Common Stock Sales Agreement Gross Sales
The gross sales during the period under a common stock sales agreement.
Intangible Assets [Abstract]
Intangible Assets Abstract.
Weighted average common shares outstanding, basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Loss in fair value of contingent consideration
Change In Fair Value Of Contingent Considerations
Change in fair value of contingent considerations.
City Area Code
City Area Code
Aggregate intrinsic value, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Accrued general and administrative
Accrued General And Administrative Current
Accrued general and administrative current.
Number of shares, Forfeited
Stock option to purchase shares of common stock cancelled
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Tranche Three Sub Tranche One
Tranche Three Sub Tranche One [Member]
Tranche three sub tranche one.
Issued
Warrants Issued In Period Weighted Average Exercise Price
Weighted average price at which warrants were issued.
Total liabilities
Liabilities
Document Period End Date
Document Period End Date
Issuance costs
Payments of Stock Issuance Costs
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Recent Accounting Pronouncements
Weighted average grant date fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Lessee, Operating Lease, Lease Not yet Commenced, Commencement Date
Lessee, operating lease, lease not yet commenced, commencement date.
Concentration of Credit Risk
Risks and Uncertainties [Abstract]
2023
Finite-Lived Intangible Asset, Expected Amortization, Year One
Statistical Measurement
Statistical Measurement [Axis]
Income Taxes
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Subsequent Event [Line Items]
Related Party
Related Party [Axis]
Total assets
Assets
Previoiusly Reported
Previously Reported [Member]
Common stock sales agreement, commission percentage
Common Stock Sales Agreement Commission Percentage
The commission percentage paid under a common stock sales agreement.
Payment terms
Revenue, Performance Obligation, Description of Payment Terms
Loan payable, long-term
Loan payable, long-term
Long-Term Debt, Excluding Current Maturities
Tax credit
Income From N Y C Biotechnology Credit
Represents the amount of other income from NYC Biotechnology Credit.
License Agreements
License Agreements Disclosure [Text Block]
The entire disclosure for license agreements.
Net loss per common share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Accounts Receivable, net
Accounts Receivable [Policy Text Block]
Number of shares, Expired
Share Based Compensation Arrangement By Share Based Payment Award Options Expired In Period
Share based compensation arrangement by share based payment award options expired in period.
Schedule of Potentially Dilutive Securities
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Less: unamortized debt discount, long term
Debt Instrument, Unamortized Discount, Noncurrent
Ending Balance (Level 3)
Beginning Balance
Fair value of contingent consideration
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Revision of Prior Period [Axis]
Document Fiscal Period Focus
Document Fiscal Period Focus
Number of financial institutions that hold the Company's cash
Number Of Financial Institutions Holding Deposits
Represents the number of financial institutions holding the Company's cash.
Issuance of common stock upon financing
Stock Issued During Period Value Financing
Value of stock issued pursuant to a financing arrangement during the period.
Accrued expenses and other current liabilities
Accrued expenses and other current liabilities
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accrued Expenses and Other Current Liabilities
Business combination, recognized identifiable assets acquired and liabilities assumed, current liabilities, accrued expenses and other current liabilities.
NOL carryforwards expiration year
Operating Loss Carryforwards Expiration Year
Operating loss carryforwards expiration year.
Class Of Warrant Or Right [Table]
Class of Warrant or Right [Table]
Accounts receivable, net
Increase (Decrease) in Accounts Receivable
Deferred Tax Assets, Valuation Allowance, Total
Less valuation allowance
Deferred Tax Assets, Valuation Allowance
Preferred stock, $0.0001 par value per share (10,000,000 shares authorized, none issued and outstanding at December 31, 2022 and December 31, 2021, respectively)
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Pfizer Inc
Pfizer Inc [Member]
Information pertaining to Pfizer, Inc.
Number of Asian markets
Number of Asian Markets
Number of Asian markets.
Counterparty Name
Counterparty Name [Domain]
Total operating lease liabilities
Present value of operating lease liabilities
Operating Lease, Liability
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Weighted average grant date fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Number of shares, Cancelled
Share Based Compensation Arrangement By Share Based Payment Award Options Cancelled In Period
Share based compensation arrangement by share based payment award options cancelled in period.
Statement of Financial Position [Abstract]
Entity File Number
Securities Act File Number
Scenario
Scenario [Domain]
Statement of Cash Flows [Abstract]
Cash Equivalents
Cash Equivalents, at Carrying Value [Abstract]
Valuation Approach and Technique [Domain]
Common stock to be issued if warrants are exercised (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Class Of Warrant Or Right [Line Items]
Class of Warrant or Right [Line Items]
Geographical [Domain]
Statistical Measurement
Statistical Measurement [Domain]
Statement of Stockholders' Equity [Abstract]
Sale of Stock
Sale of Stock [Axis]
Amortization of debt discount related issuance costs and warrants
Amortization of debt discount
Amortization of Debt Discount (Premium)
Accrued research and development
Accrued Research And Development Current
Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Common stock sales agreement, shares unsold amount
Common Stock Sales Agreement Shares Unsold Amount
Common stock sales agreement shares unsold amount.
Auditor Location
Schedule of Operating Lease Expense
Lease, Cost [Table Text Block]
Interest Expense
Deferred Tax Assets Interest Expense
Amount, before allocation of valuation allowances, of deferred tax asset attributable to interest expenses.
Auvelity
Auvelity [Member]
Auvelity.
Net operating loss carryback period
C A R E S Act Net Operating Loss Carryback Period
CARES Act net operating loss carryback period.
Subsequent Events [Abstract]
Fair Value Measurements
Fair Value Disclosures [Text Block]
Weighted average exercise price, Expired
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
2014-09
Accounting Standards Update 2014-09 [Member]
Weighted average contractual term, Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Proceeds from issuance of common stock upon exercise of options
Proceeds from Stock Options Exercised
Proceeds from issuance of common stock upon financing, net
Proceeds from Issuance of Common Stock
Long-term Debt, Type
Long-Term Debt, Type [Axis]
Research and development credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Contingent consideration, measurement input
Business Combination, Contingent Consideration, Liability, Measurement Input
Concentration of Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Non-current inventory and other assets
Non Current Inventory and Other Assets
Non-current inventory and other assets
Antidilutive Securities
Antidilutive Securities [Axis]
Impact of COVID-19
Impact Of C O V I D19 Policy [Text Block]
Impact of COVID-19.
Term loan advance
Maximum loan amount
Line of Credit Facility, Maximum Borrowing Capacity
Schedule of Warrant Activity
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Total
Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net
Outstanding principle and advances under the loans agreement exceeds 65 million
Outstanding Advances Under Loan Agreement Equals Or Exceeds Sixty Five Million [Member]
Represents the information if the outstanding principle and advances under loan agreement exceeds fifty five million.
Credit Facility [Domain]
Subsequent Events [Text Block]
Subsequent Events
Weighted average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Credit Facility [Axis]
Compensation cost not yet recognized related to unvested RSUs
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Net Loss
Business Acquisition, Pro Forma Net Income (Loss)
Royalty payments
Milestone payments or royalties
Royalty Expense
2022 Shelf Registration
Two Thousand Twenty Two Shelf Registration [Member]
Two thousand twenty two shelf registration.
Development milestones
Development Milestones
Development milestones.
Selling General and Administrative
General and Administrative Expense [Member]
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Unrecognized compensation cost related to non-vested stock options expected to be recognized
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Current Fiscal Year End Date
Current Fiscal Year End Date
Business combination purchase price allocated to goodwill deductible in number of years
Business Combination Purchase Price Allocated To Goodwill Deductible In Number Of Years
Business combination purchase price allocated to goodwill deductible in number of years.
Liability Class [Axis]
2022 Warrants
Warrants 2022 [Member]
Warrants 2022 member.
2019 Shelf Registration
Two Thousand Nineteen Shelf Registration [Member]
Two thousand nineteen shelf registration.
Depreciation, Total
Depreciation
Depreciation
Exercised
Warrants exercised
Warrants Exercised In Period
Number of warrants (or share units) exercised during the current period.
Prepaid expenses and other current assets
Increase Decrease In Prepaid Expense And Other Assets Current
The increase (decrease) during the reporting period in the value of prepaid expenses and other current assets not separately disclosed in the statement of cash flows, for example, deferred expenses, intangible assets, or income taxes.
Foreign Rate Differential
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Other Assets, Noncurrent, Total
Other assets
Other Assets, Noncurrent
Entity Address, Address Line One
Entity Address, Address Line One
Repayments of Long-term Debt, Total
Repayment of principal on term loan
Repayment of principal on term loan
Repayments of Long-Term Debt
Document Annual Report
Document Annual Report
Quarterly Financial Information Disclosure [Abstract]
2015 Plan
Two Thousand Fifteen Equity Compensation Plan [Member]
Represents information pertaining to the 2015 Equity Compensation Plan.
AXS-05
Axs05 [Member]
Represents information pertaining to AXS-05.
Supplemental disclosures of cash flow information:
Supplemental Cash Flow Information [Abstract]
Lease, expiration date
Lease Expiration Date
Beneficial ownership percentage
Beneficial Ownership Percentage
Beneficial ownership percentage.
Tranche Three Sub Tranche Two
Tranche Three Sub Tranche Two [Member]
Tranche three sub tranche two.
Contingent Consideration Type [Domain]
December 2019 Sales Agreement
December Two Thousand Nineteen Sales Agreement [Member]
December two thousand nineteen sales agreement.
Income tax benefit
Income Tax Expense (Benefit), Total
Income tax expense (benefit)
Income Tax Expense (Benefit)
Proceeds from draw down of debt
Proceeds from Long-Term Lines of Credit
Income Taxes
Income Tax Disclosure [Text Block]
Preferred Stock, Shares Issued, Total
Preferred stock, shares issued
Preferred Stock, Shares Issued
Charitable Contribution
Deferred Tax Assets Charitable Contribution
Amount, before allocation of valuation allowances, of deferred tax asset attributable to charitable contribution.
Payments to Acquire Property, Plant, and Equipment, Total
Purchases of equipment
Payments to Acquire Property, Plant, and Equipment
Stock based compensation - Excess tax benefit
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Income Tax Disclosure [Abstract]
Jazz Pharmaceuticals Plc
Jazz Pharmaceuticals Plc [Member]
Jazz pharmaceuticals Plc.
Royalty Agreements
Royalty Agreements Disclosure [Text Block]
Royalty agreements disclosure text block
Line Of Credit Facility [Table]
Line of Credit Facility [Table]
Revenue Recognition
Disaggregation of Revenue [Abstract]
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in accounting principle, accounting standards update, adoption date
Cash pay interest multiplier
Debt Instrument Cash Pay Interest Multiplier
Represents the multiplier used for the cash pay interest under the debt instrument.
Dividend Yield
Measurement Input, Expected Dividend Rate [Member]
Shares issued
Stock Issued During Period, Shares, New Issues
upfront payment received
upfront payment received
Add: accreted liability of final payment fee
Debt Instrument Accreted Liability Of Final Payment Fee
Amount of accreted liability of final payment fee.
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Accrued expenses
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Exercise of warrants
Stock Issued During Period Value Warrants Exercised
Value of stock issued as a result of the exercise of warrants.
Fair value share price
Share Price Fair Value
Fair value price of a single share of a number of saleable stocks of a company
Number of reporting units
Number of Reporting Units
Total operating expenses
Costs and Expenses
Fair Value Hierarchy and NAV [Axis]
Stock Based Compensation
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Lease commencement date
Lease Commencement Date
Lease commencement date.
Auditor Name
Accrued Liabilities and Other Liabilities [Abstract]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Equity [Abstract]
Segment and Geographic Information
Segment Reporting, Disclosure of Entity's Reportable Segments [Abstract]
Weighted average exercise price, Forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Proceeds from issuance of common stock, net
Stock Issued During Period Value New Issues Net
Net equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.
Loss from operations
Loss from operations
Operating Income (Loss)
Tax Credit
Tax Credit Policy Policy [Text Block]
Disclosure of accounting policy for tax credits.
Base interest rate
Debt Instrument, Interest Rate, Stated Percentage
Deferred tax adjustment
Effective Income Tax Rate Reconciliation, Prior Year Income Taxes, Percent
Stock vested during period value restricted common stock award.
Stock Vested During Period Value Restricted Common Stock Award
Issuance of common stock upon vesting of RSUs
Lessee, operating lease, option to extend
Lessee, Operating Lease, Option to Extend
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares, Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares, Beginning Balance
Non-vested options outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares
Related Party
Related Party [Domain]
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional paid-in capital
Additional Paid in Capital, Common Stock
Placement agent warrants
Placement Agent Warrants [Member]
Represents placement agent warrants.
Tranche Two Sub-Tranche Two
Tranche Two Sub Tranche Two [Member]
Tranche two sub tranche two.
Scenario
Scenario [Axis]
Warrants exercisable
Number Of Warrants Exercisable
Number of warrants exercisable.
Class of Warrant or Right
Class of Warrant or Right [Domain]
Entity Filer Category
Entity Filer Category
Fair Value by Liability Class [Domain]
Entity Current Reporting Status
Entity Current Reporting Status
Other current assets
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Other
Inventories, net
Inventories, net
Inventory, Net
Non-current inventory and other assets
Inventory, Noncurrent
Inventory, Noncurrent, Total
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Intrinsic value of stock options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Prime Rate
Prime Rate [Member]
Inventory
Inventory Disclosure [Text Block]
Fair value of contingent consideration
Business Combination Consideration Fair Value of Contingent Consideration
Business combination consideration fair value of contingent consideration.
Stockholders' Equity
Stockholders' Equity Note Disclosure [Text Block]
Vesting of stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares
Business Combination
Business Combinations [Abstract]
Total
Finite-Lived Intangible Assets, Net
Finite-Lived Intangible Assets, Net, Ending Balance
Finite-Lived Intangible Assets, Net, Beginning Balance
Total stockholders’ equity
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Interest expense, net
Investment Income, Net, Total
Interest and amortization of debt discount expense
Investment Income, Net
Probability weighted income approach
Valuation, Income Approach [Member]
Contingent Consideration
Commitments and Contingencies, Policy [Policy Text Block]
Percentage of aggregate amount of loan
Debt Instrument Aggregate Amount Percentage
Percentage of aggregate amount of loan.
Long-Term Debt, Maturity, Year Two
2023
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Percentage of final payment fee
Debt Instrument Final Payment Fee Threshold Percentage Of Debt Outstanding
The final payment fee to be paid under the debt arrangement as a percentage of aggregate amount of all term loan advances minus the aggregate amount of repayments made.
Entity Tax Identification Number
Entity Tax Identification Number
Income Statement Location
Income Statement Location [Axis]
Number of shares, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Common stock, $0.0001 par value per share (150,000,000 shares authorized, 43,498,617 and 37,816,794 shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively)
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Value of common stock
Common Stock, Value, Issued
Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Abstract]
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Minimum product revenue percent
Long Term Debt Additional Drawn Minimum Revenue Percent
The minimum percentage of revenue should be achieved under the debt instrument.
Issuance of warrants in connection with debt financing
Warrants issued with debt financing.
Warrants Issued With Debt Financing
Inventory reserves
Inventory Valuation Reserves
Equity Components
Equity Components [Axis]
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Total
Non-cash compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits
Business combination, transaction costs
Business Combination, Acquisition Related Costs
Accounting Standards Update [Domain]
Thereafter
Finite Lived Intangible Assets Amortization Expense After Year Four
Finite lived intangible assets amortization expense after year four.
Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Warrants exercisable date
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Entity Emerging Growth Company
Entity Emerging Growth Company
Summary of Balance Sheet Classification of Inventory
Schedule of Inventory, Noncurrent [Table Text Block]
Schedule of Business Acquisitions, by Acquisition [Table]
Operating expenses:
Operating Expenses [Abstract]
Volatility
Measurement Input, Price Volatility [Member]
2016 Warrants
Warrants2016 [Member]
Information pertaining to 2016 warrants.
Goodwill [Line Items]
Measurement Period Adjustments
Revision of Prior Period, Adjustment [Member]
Stock vested during period shares restricted common stock award.
Stock Vested During Period Shares Restricted Common Stock Award
Issuance of common stock upon vesting of RSUs (in shares)
Common stock, voting right per share
Equity Instrument Voting Rights Per Share
Represents the number of votes per share each holder of shares is entitled to.
Revenue Recognition
Revenue [Policy Text Block]
Cost of product sales
Cost of Revenue
Cost of Revenue, Total
Weighted average expected term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Lessee, Operating Lease, Liability, to be Paid [Abstract]
Investment, Name
Investment, Name [Axis]
Entity Voluntary Filers
Entity Voluntary Filers
True-ups
Effective Income Tax Rate Reconciliation True-ups
Effective income tax rate reconciliation true-ups.
Volatility, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Accrued expenses and other current liabilities
Increase (Decrease) in Other Accounts Payable and Accrued Liabilities
Weighted average contractual term
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Minimum percentage of cash to be maintained as a security
Long Term Debt Additional Drawn Covenant Minimum Cash To Be Maintained As Security Percent
The minimum percentage of cash to be maintained under debt instruments.
Document Transition Report
Document Transition Report
Long-Term Debt, Maturity, Year Three
2024
Weighted average grant date fair value, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Tranche One
Tranche One [Member]
Tranche one.
SVB Securities
SVB Securities Limited Liability Company [Member]
SVB Securities Limited Liability Company.
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Weighted average exercise price, Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Number of shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Tax Period
Tax Period [Domain]
Accounts receivables, net
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Fixed Assets
Deferred Tax Assets, Property, Plant and Equipment
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Amortization of final payment fee
Amortization of debt issuance costs
Amortization of Debt Issuance Costs
Total
Accrued expenses and other current liabilities
Accounts Payable and Other Accrued Liabilities, Current
Revision of Prior Period [Domain]
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Lessee operating lease liability payments due after year four.
Lessee Operating Lease Liability Payments Due After Year Four
Thereafter
Operating lease liability, current portion
Operating Lease, Liability, Current
Upfront cash payment
Initial Cash Payment Per Collaboration Agreement
Initial Cash Payment Per Collaboration Agreement.
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
License agreement royalty, maximum reduction percent as a result of required third party payments
License Agreement Royalty Due Maximum Reduction Percentage As Result Of Required Payments To Third Parties
Represents the maximum reduction percentage of the royalty due as a result of required payments to third parties.
Schedule of Preliminary Purchase Consideration
Schedule of Business Acquisition of Preliminary Purchase Consideration [Table Text Block]
Schedule of business acquisition of preliminary purchase consideration.
Payment, Tax Withholding, Share-Based Payment Arrangement
Payments of tax withholdings on stock award
Payments of tax withholdings on stock award
Schedule of Principal Payments
Schedule of Maturities of Long-Term Debt [Table Text Block]
Schedule of fair value measurements of contingent consideration recurring include significant unobservable inputs
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Entity Registrant Name
Entity Registrant Name
Advertising costs
Advertising Expense
Total
Liabilities, Fair Value Disclosure
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Net Loss per Common Share
Earnings Per Share [Text Block]
Summary of Black-Scholes Option Valuation Assumptions
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Non-cash stock-based compensation expense related to plan cancelled
Allocated Share Based Compensation Expense Related To Plan Cancelled
Allocated share based compensation expense related to plan cancelled.
Sales
Revenues
Revenues, Total
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Total
Equipment, net
Property, Plant and Equipment, Net
Weighted average contractual term, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Debt Instrument, Unamortized Discount, Total
Fair value of warrant recorded as a debt discount
Debt Instrument, Unamortized Discount
Award Type
Award Type [Domain]
Statement [Line Items]
Statement [Line Items]
Operating Lease, Expense
Rent expense
Exercised
Warrants Exercised In Period Weighted Average Exercise Price
Weighted average price at which warrants were exercised.
Weighted average exercise price, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Goodwill adjustment
Goodwill, Purchase Accounting Adjustments
Accounting Standards Update and Change in Accounting Principle [Abstract]
Recent Accounting Pronouncements
Title of 12(b) Security
Title of 12(b) Security
Gross Carrying Amount
Finite-Lived Intangible Assets, Gross
Finite-Lived Intangible Assets, Gross, Total
Term of warrants (in years)
Class Of Warrant Or Right Term
Period during which warrants are active, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Antecip
Affiliated Entity [Member]
Common Stock
Common Stock [Member]
Cost of product sales (excluding amortization and depreciation)
Cost of Goods and Service, Excluding Depreciation, Depletion, and Amortization
Cost of Goods and Service, Excluding Depreciation, Depletion, and Amortization, Total
Tranche One Sub Tranche Four
Tranche One Sub Tranche Four [Member]
Tranche one sub tranche four.
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Equity Component
Equity Component [Domain]
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
Product sales, net
Product sales
Revenue from Contract with Customer, Excluding Assessed Tax
Entity Address, State or Province
Entity Address, State or Province
Lessee, Operating Lease, Liability, to be Paid, Year Four
2025
Geographical [Axis]
Tranche One Sub Tranche Two
Tranche One Sub Tranche Two [Member]
Tranche one sub tranche two.
Net (decrease) increase in cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Document Type
Document Type
Interest paid
Interest Paid, Excluding Capitalized Interest, Operating Activities
Schedule of Unaudited Pro Forma Summary Presents Consolidated Information
Business Acquisition, Pro Forma Information [Table Text Block]
Goodwill
Goodwill Disclosure [Text Block]
Net federal operating loss carryforward
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Adjustments to Additional paid-in capital Shares tendered for withholding taxes.
Adjustments To Additional Paid In Capital Shares Tendered For Withholding Taxes
Shares tendered for withholding taxes
Accounts Receivable, net
Receivables [Abstract]
Entity Shell Company
Entity Shell Company
Warrants outstanding
Warrants outstanding beginning balance
Warrants outstanding ending balance
Class of Warrant or Right, Outstanding
Inventories, net
Increase (Decrease) in Inventories
Increase (Decrease) in Inventories, Total
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Inventory step-up fair value
Business Combination, Step-Up Inventory Fair Value
Business combination, step-up inventory fair value.
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Accounts receivable, reserves for variable consideration
Accounts Receivable Allowance, Reserve for Variable Consideration
Accounts receivable allowance, reserve for variable consideration.
Percentage of facility fee to be paid
Percentage Of Facility Fee To Be Paid
Percentage of facility fee to be paid.
Fair Value, Recurring and Nonrecurring [Table]
Exercise price
Warrant Exercise Price
The per share exercise price of warrants
Loss Contingencies [Line Items]
Loss Contingencies [Line Items]
Accrued selling, general and administrative
Accrued Selling, General and Administrative Current
Accrued selling, general and administrative current.
Term loan 2020 tranche three
Term Loan2020 Tranche Three [Member]
Represents about term loan tranche three.
Security Exchange Name
Security Exchange Name
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Revenue Discount Rate Increases or Decreases by Approximately 1%
Revenue Discount Rate Increases or Decreases by One Percentage [Member]
Revenue discount rate increases or decreases by one percentage.
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Expected vesting period for non-vested share-based compensation
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted average contractual term, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Mandatory conversion, warrant price premium as a percent of the conversion price
Class Of Warrant Or Right Mandatory Conversion Price Premium Percentage
The warrant price premium, as a percent of the conversion price, automatically applied as a result of a mandatory conversion.
Cash paid for business combination
Cash at settlement
Payments to Acquire Businesses, Gross
Commitments and Contingencies Disclosure [Abstract]
Debt Instrument Prepayment Occurs On Or After First Anniversary And Prior To Second Anniversary Of First Amendment Closing Date [Member]
Debt instrument prepayment occurs on or after first anniversary and prior to second anniversary of first amendment closing date.
Prepayment Occurs on or After First Anniversary and Prior to Second Anniversary of First Amendment Closing Date
Second Amendment To Loan and Security Agreement
Second Amendment To Loan and Security Agreement [Member]
Second amendment to loan and security agreement.
Total operating lease expense
Operating Lease, Cost
Accrued Interest
Interest Payable, Current
Restricted Stock Units
Restricted Stock Units
Restricted Stock Units (RSUs) [Member]
Schedule of Future Minimum Lease Payments of Operating Leases
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Setion 174 Capitlization
Deferred Tax Assets Setion 174 Capitlization
Deferred tax assets setion 174 capitlization.
Net revenues
Business Acquisition, Pro Forma Revenue
Warrants
Warrant [Member]
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Summary of Stock Option Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Business Acquisition [Line Items]
Gain (Loss) on Extinguishment of Debt, Total
Loss on extinguishment of debt
Loss on extinguishment of debt
Gain (Loss) on Extinguishment of Debt
Cost of Product Sales
Cost of Goods and Service [Policy Text Block]
Work in process
Inventory, Work in Process, Gross
Accrued royalties
Accrued Royalties, Current
Level 2
Fair Value, Inputs, Level 2 [Member]
Proceeds from Issuance of Long-term Debt, Total
Proceeds from issuance of term loan
Proceeds from Issuance of Long-Term Debt
Term Loan 2020
Term Loan2020 [Member]
Represents about term loan two thousand twenty.
Revenue Required Metric Risk Premium rate
Measurement Input, Revenue Multiple [Member]
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Schedule of Finite Lived Intangible Assets Future Amortization Expense
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Common Stock, Shares, Issued, Total
Number of common shares
Common stock, shares issued
Balance (in shares)
Balance (in shares)
Common Stock, Shares, Issued
Variable Rate
Variable Rate [Domain]
Minimum
Minimum [Member]
Number of exclusive license agreements
Number Of License Agreements
Represents the number of license agreements the Company has entered into.
Risk-free interest rate, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Leases
Lessee, Leases [Policy Text Block]
Weighted average exercise price, Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Accounting Standards Update [Axis]
Debt Instrument
Debt Instrument [Axis]
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Counterparty Name
Counterparty Name [Axis]
Entity Address, Address Line Two
Entity Address, Address Line Two
Foreign Currency Translation
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Revenues [Abstract]
Weighted average grant date fair value, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Discount Rate Increases or Decreases by Approximately 1%
Discount Rate Increases or Decreases by One Percentage [Member]
Discount rate increases or decreases by one percentage.
Amortization of intangible asset
Intangible asset amortization
Amortization of Intangible Assets
License agreement royalty as a percent of net sales
License Agreement Royalty Due Percentage Of Net Sales
Represents the percentage of net sales of products containing the licensed products, due to licensor as a royalty.
Award Type
Award Type [Axis]
Subsequent Event
Cash and contingent consideration
Total
Business Combination, Consideration Transferred
Other
Deferred tax asset, excluding valuation allowance
Deferred Tax Assets, Gross
Loss Contingencies [Table]
Loss Contingencies [Table]
Research and Development Expense, Total
Research and development expense recognized
Research and development
Research and Development Expense
Total lease payments
Lessee, Operating Lease, Liability, to be Paid
Issuance of common stock upon financing (in shares)
Stock Issued During Period Shares Financing
Number of shares of stock issued during the period pursuant to a financing arrangement.
Lease term
Lessee, Operating Lease, Term of Contract
Payment of contingent consideration
Payment Of Contingent Consideration
Payment Of Contingent Consideration
Tranche One Sub-Tranche One
Tranche One Sub Tranche One [Member]
Tranche One Sub Tranche One [Member]
Intangible Assets
Deferred Tax Assets, Goodwill and Intangible Assets
Entity Central Index Key
Entity Central Index Key
Advertising Costs
Advertising Cost [Policy Text Block]
Other permanent differences
Effective Income Tax Rate Reconciliation Permanent Differences Percent
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to income exempt from income tax because of a permanent differences.
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Eligible to receive sales-based and other milestones
Eligible to receive sales-based and other milestones
Warrant expiration date
Warrants and Rights Outstanding, Maturity Date
Contingent consideration liability, non-current
Contingent consideration, non-current
Business Combination, Contingent Consideration, Liability, Noncurrent
AXS-05 and AXS-07
Axs05 And Axs07 [Member]
Represents the information pertaining to AXS-05 and AXS-07.
Accounting Policies [Abstract]
Tranche One Sub Tranche Five
Tranche One Sub Tranche Five [Member]
Tranche one sub tranche five.
Black-Scholes option valuation assumptions
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Weighted average exercise price, Cancelled
Share Based Compensation Arrangements By Share Based Payment Award Options Cancelled In Period Weighted Average Exercise Price
Share based compensation arrangements by share based payment award options cancelled in period weighted average exercise price.
Measurement Frequency [Axis]
Interest expense
Interest Expense, Debt, Excluding Amortization
Shares available for future grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Trading days
Class Of Warrants Or Rights Weighted Average Price Trading Days
Threshold period of specified consecutive trading days within which the volume weighted average price of company's common stock.
Aggregate intrinsic value, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Sunosi
Sunosi [Member]
Sunosi.
Accrued contingent consideration, current
Contingent consideration, current
Business Combination, Contingent Consideration, Liability, Current
Subsequent Event [Table]
Measurement Input Type
Measurement Input Type [Domain]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Weighted average exercise price, Outstanding, beginning balance
Weighted average exercise price, Outstanding, ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Research and Development
Research and Development Expense [Member]
Risk-free interest rate, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Warrants and Rights Outstanding, Measurement Input
Warrants and Rights Outstanding, Measurement Input
Forecast
Forecast [Member]
Operating lease right-of-use asset obtained in exchange for operating lease liability
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Accumulated Deficit
Retained Earnings [Member]
Measurement Input Type
Measurement Input Type [Axis]
Tax Year 2017
Tax Year 2017 [Member]
Effective tax rate
Effective tax rate
Effective Income Tax Rate Reconciliation, Percent
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Schedule of Goodwill [Table]
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Goodwill from Sunosi Acquisition
Goodwill, Acquired During Period
Entity Interactive Data Current
Entity Interactive Data Current
Entity Public Float
Entity Public Float
Number of shares, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Related-Party Transactions
Related Party Transactions Disclosure [Text Block]
Supplemental non-cash investing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Related Party Transactions [Abstract]
Minimum percentage of cash to be maintained as a security following market capitalization condition
Long Term Debt Additional Drawn Covenant Minimum Cash To Be Maintained As Security With Market Capitalization Covenant Percent
The minimum percentage of cash to be maintained as security following the market capitalization conditions under the debt instruments.
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Net foreign operating loss carryforward
Deferred Tax Assets, Operating Loss Carryforwards, Foreign
Local Phone Number
Local Phone Number
2020 Warrants
Warrants2020 [Member]
Warrants 2020.
U.S. federal statutory income tax rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Schedule of Preliminary Allocation of Fair Value
Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]
Computation of Basic and Diluted Net Loss per Common Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Debt Disclosure [Abstract]
Number of approved products
Number of approved products
Number of approved products.
Summary of Quarterly Consolidated Financial Data
Quarterly Financial Information [Table Text Block]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of shares, Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Lessee, Operating Lease, Description
Lessee, operating lease, description
Warrants and Rights Note Disclosure [Abstract]
Lender Name [Axis]
Lessee, operating lease, existence of option to extend [true false]
Lessee, Operating Lease, Existence of Option to Extend [true false]
Number of shares, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Schedule of fair value of the contingent consideration remeasured
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Income Statement Location
Income Statement Location [Domain]
Risk Free Interest Rate
Measurement Input, Risk Free Interest Rate [Member]
Outstanding principle and advances under the loans agreement exceeds 55 million
Outstanding Advances Under Loan Agreement Equals Or Exceeds Fifty Five Million [Member]
Represents the information if the outstanding principle and advances under loan agreement exceeds fifty five million.
Long-Term Debt, Maturity, Year One
2022
Tranche Two Sub Tranches To One Tranche
Tranche Two Sub Tranches To One Tranche [Member]
Tranche two sub tranches to one tranche.
Selling General And Administrative Expenses
Selling, General and Administrative Expenses [Member]
Equipment, net
Equipment
Property, Plant and Equipment [Abstract]
Number of shares, Outstanding, beginning balance
Number of shares, Outstanding, ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Long-term Debt, Total
Outstanding amount
Long-Term Debt
Remaining credit facility to be drawn
Line of Credit Facility, Remaining Borrowing Capacity
Common warrants
Common Warrants [Member]
Represents common warrants.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Increase in minimum cash requirement amount
Long Term Debt Additional Drawn Covenant Minimum Cash
Long Term debt additional drawn covenant minimum cash.
Inventory Disclosure [Abstract]
Contingent Consideration by Type [Axis]
Underwritten Public Offering
Underwritten Public Offering [Member]
An underwritten sale of stock.
Number of shares, Outstanding, beginning balance
Number of shares, Outstanding, ending balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Share price
Share Price
Share Price
Upfront payment
Upfront Payment
Upfront payment.
Schedule of fair value of financial instruments measured on a recurring basis
Fair Value, Liabilities Measured on Recurring Basis [Table Text Block]
Debt Instrument, Name
Debt Instrument, Name [Domain]
Document Fiscal Year Focus
Document Fiscal Year Focus
Balance at December 31, 2021
Net Book Value at December 31, 2022
Net Book Value at December 31, 2022
Accumulated Amortization
Intangible asset, net
Intangible Assets, Net (Excluding Goodwill)
Class of Warrant or Right
Class of Warrant or Right [Axis]
Payment of debt issuance costs
Payments of Debt Issuance Costs
Foreign NOL carryforwards
Operating Loss Carryforwards Foreign
Operating loss carryforwards foreign.
Measurement period adjustment
Goodwill, Period Increase (Decrease)
Goodwill, Period Increase (Decrease), Total
Lessee, Operating Lease, Liability, to be Paid, Year Two
2023
Net loss per common share, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Weighted average exercise price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Assets
Assets [Abstract]
Volatility, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Schedule of Outstanding Debt and Unamortized Debt Discount Balances
Schedule of Long-Term Debt Instruments [Table Text Block]
Prepaid and other current assets
Prepaid Expense and Other Assets, Current
Prepayment Occurs on or After First Anniversary and Prior to Second Anniversary of the Closing Date
Debt Instrument Prepayment Occurs On Or After First Anniversary And Prior To Second Anniversary Of Closing Date [Member]
Represents the prepayment of debt occurring on or after the first anniversary and prior to the second anniversary of the Closing Date.
Fair value of contingent consideration in a business combination
Fair Value Of Contingent Consideration In A Business Combination
Fair value of contingent consideration in a business combination.
Accrued royalty payments
Accrued Royalties
Change in operating lease liability
Change In Operating Lease Liability
Change in operating lease liability.
Number of shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Liabilities and stockholders’ equity
Liabilities and Equity [Abstract]
Equipment, net
Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Deferred tax assets:
Deferred Tax Assets, Operating Loss Carryforwards, Components [Abstract]
Initial estimate (Level 3)
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Initial Estimate
Fair value measurement with unobservable inputs reconciliations recurring basis liability initial estimate.
Valuation Approach and Technique [Axis]
Net deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Term loan 2020 tranche five
Term Loan2020 Tranche Five [Member]
Represents about term loan tranche five.
Significant Risks And Uncertainties
Significant Risks and Uncertainties
Significant Risks And Uncertainties Policy Policy [Text Block]
Disclosure of accounting policy for significant risks and uncertainties.
Current assets:
Assets, Current [Abstract]
2026
Finite-Lived Intangible Asset, Expected Amortization, Year Four
2024
Finite-Lived Intangible Asset, Expected Amortization, Year Two
Exercise price of warrants (in dollars per share)
Weighted average exercise price, Beginning balance
Weighted average exercise price, Ending balance
Class of Warrant or Right, Exercise Price of Warrants or Rights
Long term debt upon milestone achievement amount
Long Term Debt upon Milestone Achievement Amount
Long term debt upon milestone achievement amount.
Schedule of Components of Deferred Tax Assets
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Goodwill
Schedule of Goodwill [Table Text Block]
Fair Value Hierarchy and NAV [Domain]
2014 Warrants
Warrants2014 [Member]
Information pertaining to 2014 warrants.
Measurement Frequency [Domain]
Issuance of warrants upon debt financing
Warrants Issued During Period Debt Financing
Warrants issued during period debt financing.
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Issued
Warrants Issued In Period
Number of warrants (or share units) issued during the current period.
Accrued sales discounts, rebates and allowances
Accrued Sales Commission, Current
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Number of shares, Cancelled
Stock option to purchase shares of common stock cancelled
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled In Period
Share based compensation arrangement by share based payment award equity instruments other than options cancelled in period.
2013 Plan
Two Thousand Thirteen Equity Compensation Plan [Member]
Two thousand thirteen equity compensation plan.
Tranche Three Sub Tranches to One Tranche
Tranche Three Sub Tranches To One Tranche [Member]
Tranche three sub tranches to one tranche.
Cover [Abstract]
Product and Service
Product and Service [Domain]
Number of shares, Vested
Number of shares, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Finished goods
Inventory, Finished Goods, Gross
Prior trading days
Consecutive Trading Days
Represents the consecutive number of trading days to determine the weighted average price per share of ordinary shares.
Warrant utilized
Warrant Utilized
The amount utilized for warrants.
Cost of Product Sales
Cost of Revenue [Abstract]
Current liabilities:
Liabilities, Current [Abstract]
Maximum [Member]
Maximum
Warrant term
Warrants and Rights Outstanding, Term
License agreement term, from first commercial sale
License Agreement Term
Period of time, after the first commercial sale of the applicable product, the license agreement is valid, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Schedule of debt approximates its fair value given its variable interest rate
Schedule of Interest and Amortization Expense for Final Payment Fee and Debt Discount [Table Text Block]
Schedule of interest and amortization expense for final payment fee and debt discount.
Schedule of Stock-Based Compensation Expense Recognized
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities
Tranche One Sub Tranche Three
Tranche One Sub Tranche Three [Member]
Tranche one sub tranche three.
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Number of not yet approved product candidates
Number of Not Yet Approved Product Candidates
Number of not yet approved product candidates.
Number of shares, Exercised
Issuance of common stock upon exercise of options (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Schedule of Inventory
Schedule of Inventory, Current [Table Text Block]
Level 3
Fair Value, Inputs, Level 3 [Member]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Interest rate basis
Debt Instrument, Basis Spread on Variable Rate
Deferred Tax Liabilities, Gross, Total
Deferred tax liability, excluding valuation allowance
Deferred Tax Liabilities, Gross
Hercules Capital Inc
Hercules Capital Inc [Member]
Hercules Capital Inc.
Cash Equivalents, at Carrying Value, Total
Cash Equivalents
Cash Equivalents, at Carrying Value
Prepayment Occurs on or After Second Anniversary and Prior to Third Anniversary of Closing Date
Debt Instrument Prepayment Occurs On Or After Second Anniversary And Prior To Third Anniversary Of Closing Date [Member]
Represents the prepayment of debt occurring after the second anniversary and prior to the third anniversary of the Closing Date.
Issuance of common stock upon exercise of options
Stock Issued During Period, Value, Stock Options Exercised
Segment and Geographic Information
Segment Reporting, Policy [Policy Text Block]
Aggregate intrinsic value, Exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Estimated useful life
Property, Plant and Equipment, Useful Life
2018 Registered Direct Offering
Two Thousand Eighteen Registered Direct Offering [Member]
Two thousand eighteen registered direct offering.
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Tax credit
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Total Outstanding Debt
Total principal payments outstanding
Long-Term Debt, Gross
2025
Finite-Lived Intangible Asset, Expected Amortization, Year Three
September 2014 Notes
Convertible Notes Payable Tranche One [Member]
Represents information pertaining to tranche one of convertible notes payable.
Term loan 2020 tranche four
Term Loan2020 Tranche Four [Member]
Represents about term loan tranche four.
Common stock, shares authorized
Common Stock, Shares Authorized
March 2022 Sales Agreement
March Two Thousand Twenty Two Sales Agreement [Member]
March Two Thousand Twenty Two Sales Agreement [Member]
Percentage of prepayment penalty
Debt Instrument Prepayment Penalty Percentage
Represents the prepayment penalty percentage on principal amount of debt.
Trading Symbol
Trading Symbol
Minimum cash to be maintain as a first priority security interest
Long Term Debt Additional Drawn Covenant Minimum Cash As Security Interest
The minimum amount of cash should be maintained as first priority security interest under the terms of debt instrument.
December 2019, August 222 and March 2022 Sales Agreement
December Two Thousand Nineteen March Two Thousand Twenty Two and August Two Thousand Twenty Two Sales Agreement [Member]
December two thousand nineteen, march two thousand twenty two and august two thousand twenty two sales agreement.
Selling, general and administrative
Selling, General and Administrative Expense
Selling, General and Administrative Expense, Total
Title of Individual
Title of Individual [Domain]
Subsequent Event Type [Axis]
Other
Deferred Tax Assets, Other
Amortization of operating lease right-of-use asset
Operating Lease, Right-of-Use Asset, Amortization Expense
Term Loan
Term Loan [Member]
Term loan.
Tranche Two Sub-Tranche Three
Tranche Two Sub Tranche Three [Member]
Tranche two sub tranche three.
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Payments
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements
Plan Name
Plan Name [Axis]
2019 Term Loan
Term Loan2019 [Member]
This member stands for Term Loan 2019.
Schedule Of Related Party Transactions By Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Title of Individual
Title of Individual [Axis]
Director
Director [Member]
Common stock, par value
Common Stock, Par or Stated Value Per Share
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Schedule of RSU Activity
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Term Loan 2019, Tranche Two
Term Loan2019 Tranche Two [Member]
This member stands for 2019 Term loan Tranche Two.
Number of shares, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Weighted average exercise price, Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Developed technology
Business Combination Recognized Identifiable Assets Acquired and Liabilities Assumed Current Assets Developed Technology
Business combination recognized identifiable assets acquired and liabilities assumed current assets developed technology.
Loan and Security Agreement
Long-Term Debt [Text Block]
Exercise of warrants (in shares)
Stock Issued During Period Shares Stock Warrants Exercised
Number of shares of stock issued as a result of the exercise of warrants.
Long-term Debt, Type
Long-Term Debt, Type [Domain]
Antidilutive securities
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount