Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Volatility, maximum
Lessee, operating lease, description
Lessee, Operating Lease, Description
The entire disclosure for warrants and rights.
Warrants And Rights Note Disclosure [Text Block]
Warrants
Lease Expiration Date
Lease, expiration date
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Vesting period
This member stands for 2016 Original Term Loan.
Original Term Loan2016 [Member]
Original Term Loan 2016
Prepayment Occurs Prior to First Anniversary of First Amendment Closing Date
Debt instrument prepayment occurring prior to first anniversary of first amendment closing date.
Debt Instrument Prepayment Occurring Prior To First Anniversary Of First Amendment Closing Date [Member]
Segment Reporting, Policy [Policy Text Block]
Segment and Geographic Information
Two thousand sixteen shelf registration.
Two Thousand Sixteen Shelf Registration [Member]
2016 Shelf Registration
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
Weighted average contractual term
Operating Loss Carryforwards
NOL carryforwards
Operating Loss Carryforwards, Total
Fair value of issued nonredeemable common stock (or common stock redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable common shares, par value and other disclosure concepts are in another section within stockholders' equity.
Common Stock Fair Value
Fair value of common stock
Auditor Location
Cash
Cash at end of period
Cash at beginning of period
Operating Expenses [Abstract]
Operating expenses:
Operating Income (Loss)
Loss from operations
Operating Income (Loss), Total
Schedule of Long-term Debt Instruments [Table Text Block]
Schedule of Outstanding Debt and Unamortized Debt Discount Balances
Entity Emerging Growth Company
Entity Emerging Growth Company
Income Tax Disclosure [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Weighted average grant date fair value, Forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Shares available for future grant
Payments to Acquire Property, Plant, and Equipment
Purchases of equipment
Payments to Acquire Property, Plant, and Equipment, Total
Common stock, $0.0001 par value per share (150,000,000 shares authorized, 37,816,794 and 37,374,088 shares issued and outstanding at December 31, 2021 and December 31, 2020, respectively
Common Stock, Value, Issued
Value of common stock
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Schedule of RSU Activity
Entity Address, State or Province
Entity Address, State or Province
Liabilities
Total liabilities
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Debt, Policy [Policy Text Block]
Debt Issuance Costs
Deferred tax assets leasing arrangements.
Deferred Tax Assets Leasing Arrangements
Lease Liability
Number of days to achieve second milestone following such date.
Threshold Days To Achieve Second Milestone
Period to achieve second milestone
The authorized amount under a common stock sales agreement.
Common Stock Sales Agreement Authorized Amount
Common stock sales agreement, authorized amount
Payments of tax withholdings on stock award
Payments of tax withholdings on stock award
Payment, Tax Withholding, Share-based Payment Arrangement
License Agreement Terms [Member]
License Agreement
Information pertaining to 2019 warrants.
Warrants2019 [Member]
2019 Warrants
Debt instrument maturity, month and year
Debt instruments maturity, month and year.
Debt Instruments Maturity Month And Year
Represents about term loan tranche one.
Term Loan2020 Tranche One [Member]
Term loan 2020 tranche one
Weighted Average Number of Shares Outstanding, Basic and Diluted
Weighted average common shares outstanding, basic and diluted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Number of shares
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Schedule of Warrant Activity
This member stands for first amended term loan.
First Amendment Term Loan [Member]
Amended Term Loan 2016
General and Administrative Expense [Member]
General and Administrative
Line of Credit Facility, Remaining Borrowing Capacity
Remaining credit facility to be drawn
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted average contractual term, Exercisable
Represents the number of late-stage candidates included in the Company's product candidate portfolio.
Number Of Late Stage Product Candidates
Number of late-stage candidates in Company's product candidate portfolio
Prepayment Occurs on or After Second Anniversary and Prior to Third Anniversary of First Amendment Closing Date
Debt instrument prepayment occurs on or after second anniversary and prior to third anniversary of first amendment closing date.
Debt Instrument Prepayment Occurs On Or After Second Anniversary And Prior To Third Anniversary Of First Amendment Closing Date [Member]
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Schedule of Related Party Transactions, by Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
City Area Code
City Area Code
Represents about term loan tranche two.
Term Loan2020 Tranche Two [Member]
Term loan 2020 tranche two
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Black-Scholes Option Valuation Assumptions
Deferred Tax Assets, Gross
Deferred tax asset, excluding valuation allowance
Deferred Tax Assets, Net of Valuation Allowance
Net deferred tax assets
Effective cash pay interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium.
Debt Instrument Threshold Cash Pay Interest Rate
Cash pay interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted average grant date fair value
Change in accounting principle, accounting standards update, adopted
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted average exercise price, Forfeited
The final payment fee at extinguishment of debt.
Extinguishment Of Debt Fee Amount
Final payment fee
Class of Warrant or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Potentially Dilutive Securities
The amount of future payments payable under the collaboration arrangement.
Collaboration Arrangement Future Potential Payments
Future milestone payments
The minimum amount of market capital to be maintained under debt instruments.
Long Term Debt Additional Drawn Covenant Minimum Market Capitalization Amount
Minimum amount of market capital to be maintained
Stock Issued During Period, Shares, New Issues
Shares issued
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest [Abstract]
Aggregate intrinsic value
Intrinsic value lapsed
Sharebased Compensation Arrangement by Sharebased Payment Award Other than Option Lapsed Intrinsic Value
Sharebased compensation arrangement by sharebased payment award other than option lapsed intrinsic value.
Debt Instrument, Basis Spread on Variable Rate
Interest rate basis
Scenario [Axis]
Scenario
Information pertaining to 2018 warrants.
Warrants2018 [Member]
2018 Warrants
Royalty Expense
Milestone payments or royalties
Related Party [Domain]
Related Party
The aggregate noncash costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.
Noncash Research And Development Expense
Non-cash research and development license expense
Change in accounting principle, accounting standards update, immaterial effect
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Operating Lease, Liability [Abstract]
Liabilities
Minimum different from remaining percentage of cash flow
Long Term Debt Different From Remaining Drawn Covenant Minimum Cash Flow Percentage
Long term debt different from remaining drawn covenant minimum cash flow percentage.
Income Statement [Abstract]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Affiliated Entity [Member]
Antecip
Share based compensation arrangement by share based payment award equity instruments other than options cancelled weighted average grant date fair value.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled Weighted Average Grant Date Fair Value
Weighted average grant date fair value, Cancelled
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
The fair value of outstanding warrants.
Fair Value Of Warrants
Fair value
Employee-related Liabilities, Current
Accrued compensation
Employee-related Liabilities, Current, Total
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Property, Plant and Equipment, Net
Equipment, net
Property, Plant and Equipment, Net, Total
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Common Stock, Shares, Issued
Balance (in shares)
Balance (in shares)
Common stock, shares issued
Number of common shares
Common Stock, Shares, Issued, Total
The period of unpaid invoices after threshold period respective amount should be keep as a security under the debt instruments.
Long Term Debt Additional Drawn Covenant Additional Security Unpaid Invoices Period
Period of unpaid invoices amount maintain as security
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of shares, Forfeited
Tax cuts and jobs act net operating loss carryovers and carry backs offset percentage.
Tax Cuts And Jobs Act Net Operating Loss Carryovers And Carry Backs Offset Percentage
Net operating loss carryovers and carry backs offset percentage
Represents the prepayment of debt occurring prior to first anniversary of closing date.
Debt Instrument Prepayment Occurring Prior To First Anniversary Of Closing Date [Member]
Prepayment Occurs Prior to First Anniversary of Closing Date
Subject to FDA Approval of AXS 05 and AXS 07
Subject to FDA approval of AXS zero five and AXS zero seven.
Subject To FDA Approval Of AXS Zero Five And AXS Zero Seven [Member]
Deferred Tax Liabilities, Gross
Deferred tax liability, excluding valuation allowance
Deferred Tax Liabilities, Gross, Total
Operating Lease, Right-of-Use Asset
Right-of-use asset - operating lease
The gross sales during the period under a common stock sales agreement.
Common Stock Sales Agreement Gross Sales
Common stock sales agreement, gross sales
Security Exchange Name
Security Exchange Name
Statistical Measurement [Domain]
Statistical Measurement
Risks and Uncertainties [Abstract]
Concentration of Credit Risk
2024
Long-Term Debt, Maturity, Year Three
Accrued general and administrative current.
Accrued General And Administrative Current
Accrued general and administrative
2019-12
Accounting Standards Update 2019-12 [Member]
Measurement Input, Price Volatility [Member]
Volatility
Subsequent Event Type [Domain]
Weighted average price at which warrants were issued.
Warrants Issued In Period Weighted Average Exercise Price
Issued
Line of Credit Facility, Maximum Borrowing Capacity
Maximum loan amount
Debt Disclosure [Abstract]
SVB Leerink limited liability company.
Leerink Partners Limited Liability Company [Member]
SVB Leerink
Document Period End Date
Document Period End Date
Income Statement Location [Axis]
Income Statement Location
Warrants and Rights Outstanding, Term
Warrant term
Warrant [Member]
Warrants
Loss Contingencies [Table]
Loss Contingencies [Table]
Common Stock, Shares Authorized
Common stock, shares authorized
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Operating Lease, Liability, Current
Operating lease liability, current portion
Related Party [Axis]
Related Party
Supplemental Cash Flow Information [Abstract]
Supplemental disclosures of cash flow information:
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities
2023
Long-Term Debt, Maturity, Year Two
The commission percentage paid under a common stock sales agreement.
Common Stock Sales Agreement Commission Percentage
Common stock sales agreement, commission percentage
Interest Paid, Excluding Capitalized Interest, Operating Activities
Interest paid
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Accrued Expenses and Other Current Liabilities
Represents the amount of other income from NYC Biotechnology Credit.
Income From N Y C Biotechnology Credit
Tax credit
The entire disclosure for license agreements.
License Agreements Disclosure [Text Block]
License Agreements
Deferred Tax Liabilities, Net [Abstract]
Deferred tax liabilities:
Effective Income Tax Rate Reconciliation, Percent
Effective tax rate
Effective tax rate
Entity Address, Address Line Two
Entity Address, Address Line Two
Current Fiscal Year End Date
Current Fiscal Year End Date
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net (decrease) increase in cash
Operating Lease, Cost
Total operating lease expense
Represents the number of financial institutions holding the Company's cash.
Number Of Financial Institutions Holding Deposits
Number of financial institutions that hold the Company's cash
Value of stock issued pursuant to a financing arrangement during the period.
Stock Issued During Period Value Financing
Issuance of common stock upon financing
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lessee, operating lease, existence of option to extend [true false]
Line of Credit Facility [Line Items]
Line Of Credit Facility [Line Items]
Operating loss carryforwards expiration year.
Operating Loss Carryforwards Expiration Year
NOL carryforwards expiration year
Fair Value Measurement Inputs and Valuation Techniques [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Information pertaining to Pfizer, Inc.
Pfizer Inc [Member]
Pfizer Inc
Counterparty Name [Axis]
Counterparty Name
Assets [Abstract]
Assets
Share based compensation arrangement by share based payment award options cancelled in period.
Share Based Compensation Arrangement By Share Based Payment Award Options Cancelled In Period
Number of shares, Cancelled
2022
Lessee, Operating Lease, Liability, to be Paid, Year One
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Debt Instrument, Name [Domain]
Debt Instrument, Name
Common Stock, Par or Stated Value Per Share
Common stock, par value
Investment, Name [Axis]
Investment, Name
Additional Paid in Capital, Common Stock
Additional paid-in capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Research and Development Expense, Policy [Policy Text Block]
Research and Development Costs
Document Type
Document Type
Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued Research And Development Current
Accrued research and development
Common stock sales agreement shares unsold amount.
Common Stock Sales Agreement Shares Unsold Amount
Common stock sales agreement, shares unsold amount
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Income Taxes
Preferred stock, $0.0001 par value per share (10,000,000 shares authorized, none issued and outstanding at December 31, 2021 and December 31, 2020, respectively
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Operating Lease, Liability, Noncurrent
Operating lease liability, long-term
Payment of Financing and Stock Issuance Costs, Total
Payment of Financing and Stock Issuance Costs
Payment of debt issuance costs
Accounts Payable and Other Accrued Liabilities, Current
Accrued expenses and other current liabilities
Total
Amount, before allocation of valuation allowances, of deferred tax asset attributable to interest expenses.
Deferred Tax Assets Interest Expense
Interest Expense
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Expenses
CARES Act net operating loss carryback period.
C A R E S Act Net Operating Loss Carryback Period
Net operating loss carryback period
Assets, Current
Total current assets
Share-based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Share-based Payment Arrangement, Option [Member]
Stock Options
Stock Options
Long-term Debt, Type [Domain]
Long-term Debt, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted average contractual term, Outstanding
The amount of proceeds from first advance used to repay previous debt.
Proceeds From First Advance Used To Repay Previous Debt
First advance used to repay previous debt
Income Tax Expense (Benefit)
Income tax expense (benefit)
Income Tax Expense (Benefit), Total
Income tax benefit
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosures of non-cash financing activity:
Earnings Per Share, Basic and Diluted
Net loss per common share, basic and diluted
Earnings Per Share, Basic and Diluted, Total
Impact of COVID-19.
Impact Of C O V I D19 Policy [Text Block]
Impact of COVID-19
Antidilutive Securities [Axis]
Antidilutive Securities
Loss Contingencies [Line Items]
Loss Contingencies [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of shares, Outstanding, ending balance
Number of shares, Outstanding, beginning balance
Represents the information if the outstanding principle and advances under loan agreement exceeds fifty five million.
Outstanding Advances Under Loan Agreement Equals Or Exceeds Sixty Five Million [Member]
Outstanding principle and advances under the loans agreement exceeds 65 million
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate intrinsic value, Vested and expected to vest
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items]
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Class of Warrant or Right [Domain]
Class of Warrant or Right
Plan Name [Axis]
Plan Name
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Stock option to purchase shares of common stock cancelled
Number of shares, Forfeited
Operating Expenses
Total operating expenses
Total operating expenses
Two thousand nineteen shelf registration.
Two Thousand Nineteen Shelf Registration [Member]
2019 Shelf Registration
Number of warrants (or share units) exercised during the current period.
Warrants Exercised In Period
Warrants exercised
Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted average exercise price, Outstanding, ending balance
Weighted average exercise price, Outstanding, beginning balance
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash flows from operating activities
The increase (decrease) during the reporting period in the value of prepaid expenses and other current assets not separately disclosed in the statement of cash flows, for example, deferred expenses, intangible assets, or income taxes.
Increase Decrease In Prepaid Expense And Other Assets Current
Prepaid expenses and other current assets
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Schedule of Future Minimum Lease Payments of Operating Leases
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Class of Warrant or Right, Exercise Price of Warrants or Rights
Weighted average exercise price, Ending balance
Weighted average exercise price, Beginning balance
Exercise price of warrants (in dollars per share)
Earnings Per Share [Abstract]
2023
Lessee, Operating Lease, Liability, to be Paid, Year Two
Net Income (Loss) Attributable to Parent
Net loss
Net loss
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Income Tax Rate Reconciliation
Represents information pertaining to the 2015 Equity Compensation Plan.
Two Thousand Fifteen Equity Compensation Plan [Member]
2015 Plan
Represents information pertaining to AXS-05.
Axs05 [Member]
AXS-05
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease, discount rate
Research and Development Expense [Member]
Research and Development
Beneficial ownership percentage.
Beneficial Ownership Percentage
Beneficial ownership percentage
Document Fiscal Period Focus
Document Fiscal Period Focus
December two thousand nineteen sales agreement.
December Two Thousand Nineteen Sales Agreement [Member]
December 2019 Sales Agreement
Accounting Policies [Abstract]
Entity Address, Address Line One
Entity Address, Address Line One
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Number of shares, Outstanding, ending balance
Number of shares, Outstanding, beginning balance
Amount, before allocation of valuation allowances, of deferred tax asset attributable to charitable contribution.
Deferred Tax Assets Charitable Contribution
Charitable Contribution
Liabilities, Current
Total current liabilities
Represents the multiplier used for the cash pay interest under the debt instrument.
Debt Instrument Cash Pay Interest Multiplier
Cash pay interest multiplier
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Title of Individual [Axis]
Title of Individual
Amount of accreted liability of final payment fee.
Debt Instrument Accreted Liability Of Final Payment Fee
Add: accreted liability of final payment fee
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate, maximum
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate intrinsic value, Outstanding
Lessee, Operating Lease, Liability, to be Paid
Total lease payments
Subsequent Event [Table]
Product and Service [Domain]
Product and Service
Value of stock issued as a result of the exercise of warrants.
Stock Issued During Period Value Warrants Exercised
Exercise of warrants
Warrants and Rights Outstanding, Measurement Input
Warrants and Rights Outstanding, Measurement Input
Fair value price of a single share of a number of saleable stocks of a company
Share Price Fair Value
Fair value share price
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Lease commencement date.
Lease Commencement Date
Lease commencement date
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Net equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.
Stock Issued During Period Value New Issues Net
Proceeds from issuance of common stock, net
Disclosure of accounting policy for tax credits.
Tax Credit Policy Policy [Text Block]
Tax Credit
Issuance of common stock upon vesting of RSUs
Stock Vested During Period Value Restricted Common Stock Award
Stock vested during period value restricted common stock award.
Equity Components [Axis]
Equity Components
Proceeds from Issuance of Long-term Debt
Proceeds from issuance of term loan
Proceeds from Issuance of Long-term Debt, Total
Lease, Cost [Table Text Block]
Schedule of Lease Expense
Represents placement agent warrants.
Placement Agent Warrants [Member]
Placement agent warrants
Tax Period [Axis]
Tax Period
Assets, Current [Abstract]
Current assets:
Entity Registrant Name
Entity Registrant Name
Number of warrants exercisable.
Number Of Warrants Exercisable
Warrants exercisable
Amortization of Debt Issuance Costs
Amortization of debt issuance costs
Stockholders' Equity Note Disclosure [Text Block]
Stockholders' Equity
Entity Interactive Data Current
Entity Interactive Data Current
Prime Rate [Member]
Prime Rate
Entity Address, City or Town
Entity Address, City or Town
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Volatility, minimum
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Tax credit
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Weighted average expected term
Trading Symbol
Trading Symbol
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Summary of Initial Fair Value of Warrants Estimated using Black - Scholes Option Pricing Model
Related Party Transactions Disclosure [Text Block]
Related-Party Transactions
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash flows from investing activities
Percentage of aggregate amount of loan.
Debt Instrument Aggregate Amount Percentage
Percentage of aggregate amount of loan
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less imputed interest
The final payment fee to be paid under the debt arrangement as a percentage of aggregate amount of all term loan advances minus the aggregate amount of repayments made.
Debt Instrument Final Payment Fee Threshold Percentage Of Debt Outstanding
Percentage of final payment fee
The minimum percentage of revenue should be achieved under the debt instrument.
Long Term Debt Additional Drawn Minimum Revenue Percent
Minimum product revenue percent
Warrants issued with debt financing.
Warrants Issued With Debt Financing
Issuance of warrants in connection with debt financing
Local Phone Number
Local Phone Number
Stockholders' Equity Attributable to Parent
Ending balance
Beginning balance
Total stockholders’ equity
Subsequent Event Type [Axis]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted average exercise price
Quarterly Financial Information [Table Text Block]
Summary of Quarterly Consolidated Financial Data
Research and Development [Abstract]
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Issued, Total
Repayments of Long-term Debt
Repayment of principal on term loan
Repayment of principal on term loan
Repayments of Long-term Debt, Total
Statistical Measurement [Axis]
Statistical Measurement
Entity Small Business
Entity Small Business
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Lessee, Leases [Policy Text Block]
Leases
Information pertaining to 2016 warrants.
Warrants2016 [Member]
2016 Warrants
Share Price
Share Price
Share price
Interest Expense, Debt, Excluding Amortization
Interest expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Long-term Debt, Excluding Current Maturities
Loan payable, long-term
Loan payable, long-term
Variable Rate [Axis]
Variable Rate
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Components of Deferred Tax Assets
Issuance of common stock upon vesting of RSUs (in shares)
Stock Vested During Period Shares Restricted Common Stock Award
Stock vested during period shares restricted common stock award.
Represents the number of votes per share each holder of shares is entitled to.
Equity Instrument Voting Rights Per Share
Common stock, voting right per share
Variable Rate [Domain]
Variable Rate
Property, Plant and Equipment, Useful Life
Estimated useful life
The minimum percentage of cash to be maintained under debt instruments.
Long Term Debt Additional Drawn Covenant Minimum Cash To Be Maintained As Security Percent
Minimum percentage of cash to be maintained as a security
Class of Warrant or Right, Outstanding
Warrants outstanding ending balance
Warrants outstanding beginning balance
Warrants outstanding
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted average exercise price, Granted
Sale of Stock [Domain]
Sale of Stock
Equity [Abstract]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Plan Name [Domain]
Plan Name
Thereafter
Lessee Operating Lease Liability Payments Due After Year Four
Lessee operating lease liability payments due after year four.
2022
Long-Term Debt, Maturity, Year One
Depreciation
Depreciation
Depreciation, Total
Lessee, Operating Lease, Term of Contract
Lease term
Initial Cash Payment Per Collaboration Agreement.
Initial Cash Payment Per Collaboration Agreement
Upfront cash payment
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State taxes, net of federal benefit
Represents the maximum reduction percentage of the royalty due as a result of required payments to third parties.
License Agreement Royalty Due Maximum Reduction Percentage As Result Of Required Payments To Third Parties
License agreement royalty, maximum reduction percent as a result of required third party payments
Stock Issued During Period, Value, New Issues
Proceeds from issuance of common stock, gross
Measurement Input, Expected Dividend Rate [Member]
Dividend Yield
Quarterly Financial Information Disclosure [Abstract]
Allocated share based compensation expense related to plan cancelled.
Allocated Share Based Compensation Expense Related To Plan Cancelled
Non-cash stock-based compensation expense related to plan cancelled
Debt Instrument, Unamortized Discount
Fair value of warrant recorded as a debt discount
Debt Instrument, Unamortized Discount, Total
Proceeds from Warrant Exercises
Proceeds from issuance of common stock upon exercise of warrants
Weighted average price at which warrants were exercised.
Warrants Exercised In Period Weighted Average Exercise Price
Exercised
Cash Equivalents, at Carrying Value
Cash Equivalents
Cash Equivalents, at Carrying Value, Total
Share-based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense, Total
Prepaid Expense and Other Assets, Current
Prepaid and other current assets
Period during which warrants are active, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Class Of Warrant Or Right Term
Term of warrants (in years)
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Related Party Transactions [Abstract]
Long-term Debt, Gross
Outstanding principal amount
Total principal payments outstanding
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Warrants exercisable date
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Number of shares, Exercisable
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Shares tendered for withholding taxes
Adjustments To Additional Paid In Capital Shares Tendered For Withholding Taxes
Adjustments to Additional paid-in capital Shares tendered for withholding taxes.
Commitments and Contingencies Disclosure [Abstract]
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating lease right-of-use asset obtained in exchange for operating lease liability
Debt instrument, interest payment period
Debt instrument, interest payment period.
Debt Instrument Interest Payment Period
Investment Income, Net
Interest and amortization of debt discount expense
Investment Income, Net, Total
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value, Released
Assets
Total assets
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Issuance of common stock upon exercise of options (in shares)
Number of shares, Exercised
Statement [Line Items]
Statement [Line Items]
Liabilities and Equity
Total liabilities and stockholders’ equity
Class of Warrant or Right [Axis]
Class of Warrant or Right
The per share exercise price of warrants
Warrant Exercise Price
Exercise price
Property, Plant and Equipment [Abstract]
Equipment
Statement of Cash Flows [Abstract]
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Represents about term loan tranche three.
Term Loan2020 Tranche Three [Member]
Term loan 2020 tranche three
Title of 12(b) Security
Title of 12(b) Security
Tax Year 2018 [Member]
Tax Year 2018
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
The warrant price premium, as a percent of the conversion price, automatically applied as a result of a mandatory conversion.
Class Of Warrant Or Right Mandatory Conversion Price Premium Percentage
Mandatory conversion, warrant price premium as a percent of the conversion price
Prepayment Occurs on or After First Anniversary and Prior to Second Anniversary of First Amendment Closing Date
Debt instrument prepayment occurs on or after first anniversary and prior to second anniversary of first amendment closing date.
Debt Instrument Prepayment Occurs On Or After First Anniversary And Prior To Second Anniversary Of First Amendment Closing Date [Member]
Award Type [Domain]
Award Type
Operating lease asset.
Operating Lease Asset [Abstract]
Assets
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits
Non-cash compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Total
Schedule of Maturities of Long-term Debt [Table Text Block]
Schedule of Principal Payments
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
2025
Lessee, Operating Lease, Liability, to be Paid, Year Four
Debt Instrument, Interest Rate, Stated Percentage
Base interest rate
Represents about term loan two thousand twenty.
Term Loan2020 [Member]
Term Loan 2020
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted average exercise price, Vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Number of shares, Granted
Entity Current Reporting Status
Entity Current Reporting Status
Measurement Input Type [Domain]
Measurement Input Type
Entity Voluntary Filers
Entity Voluntary Filers
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, minimum
Scenario [Domain]
Scenario
Deferred Tax Assets, Operating Loss Carryforwards, State and Local
Net state operating loss carryforward
Investment, Name [Domain]
Investment, Name
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value, Granted
Debt Instrument, Unamortized Discount, Noncurrent
Less: unamortized debt discount, long term
Warrants and Rights Outstanding, Maturity Date
Warrant expiration date
Lessee, Operating Lease, Option to Extend
Lessee, operating lease, option to extend
Earnings Per Share, Policy [Policy Text Block]
Basic and Diluted Net Loss per Common Share
Represents the number of license agreements the Company has entered into.
Number Of License Agreements
Number of exclusive license agreements
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Stock-Based Compensation Expense Recognized
Proceeds from Issuance of Debt
Proceeds from debt
Accrued Liabilities and Other Liabilities [Abstract]
Auditor Firm ID
Long-term Debt, Type [Axis]
Long-term Debt, Type
Number of days to achieve first milestone following such date.
Threshold Days To Achieve First Milestone
Period to achieve first milestone
Income Statement Location [Domain]
Income Statement Location
Represents the percentage of net sales of products containing the licensed products, due to licensor as a royalty.
License Agreement Royalty Due Percentage Of Net Sales
License agreement royalty as a percent of net sales
Class of Warrant or Right [Table]
Class Of Warrant Or Right [Table]
Auditor Name
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted average exercise price, Exercisable
Minimum [Member]
Minimum
Number of shares of stock issued during the period pursuant to a financing arrangement.
Stock Issued During Period Shares Financing
Issuance of common stock upon financing (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted average contractual term, Vested and expected to vest
Stock Issued During Period, Value, Stock Options Exercised
Issuance of common stock upon exercise of options
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to income exempt from income tax because of a permanent differences.
Effective Income Tax Rate Reconciliation Permanent Differences Percent
Other permanent differences
Accounting Standards Update and Change in Accounting Principle [Table]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of shares, Granted
Represents the information pertaining to AXS-05 and AXS-07.
Axs05 And Axs07 [Member]
AXS-05 and AXS-07
Measurement Input, Risk Free Interest Rate [Member]
Risk Free Interest Rate
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Common stock to be issued if warrants are exercised (in shares)
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Nature of Business and Basis of Presentation
Deferred Tax Assets, Operating Loss Carryforwards, Foreign
Net foreign operating loss carryforward
Document Annual Report
Document Annual Report
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Black-Scholes option valuation assumptions
Deferred Tax Assets, Valuation Allowance
Less valuation allowance
Deferred Tax Assets, Valuation Allowance, Total
Share based compensation arrangements by share based payment award options cancelled in period weighted average exercise price.
Share Based Compensation Arrangements By Share Based Payment Award Options Cancelled In Period Weighted Average Exercise Price
Weighted average exercise price, Cancelled
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash flows from financing activities
Debt Instrument [Axis]
Debt Instrument
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency Translation
Entity Filer Category
Entity Filer Category
Income Tax, Policy [Policy Text Block]
Income Taxes
Threshold period of specified consecutive trading days within which the volume weighted average price of company's common stock.
Class Of Warrants Or Rights Weighted Average Price Trading Days
Trading days
Document Fiscal Year Focus
Document Fiscal Year Focus
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Number of shares, Vested and expected to vest
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Interest Payable, Current
Accrued Interest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value
Deferred Tax Assets, Operating Loss Carryforwards, Components [Abstract]
Deferred tax assets:
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Income Tax Disclosure [Text Block]
Income Taxes
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares
Non-vested options outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares, Beginning Balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares, Ending Balance
Maximum
Maximum [Member]
Entity Central Index Key
Entity Central Index Key
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares
Vesting of stock options
2026
Long-Term Debt, Maturity, Year Five
Measurement Input Type [Axis]
Measurement Input Type
Rent expense
Operating Lease, Expense
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash Equivalents
Entity Tax Identification Number
Entity Tax Identification Number
Equity Component [Domain]
Equity Component
The minimum percentage of cash to be maintained as security following the market capitalization conditions under the debt instruments.
Long Term Debt Additional Drawn Covenant Minimum Cash To Be Maintained As Security With Market Capitalization Covenant Percent
Minimum percentage of cash to be maintained as a security following market capitalization condition
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Gain (Loss) on Extinguishment of Debt
Loss on extinguishment of debt
Loss on extinguishment of debt
Gain (Loss) on Extinguishment of Debt, Total
Property, Plant and Equipment, Policy [Policy Text Block]
Equipment
Recent Accounting Pronouncements
Accounting Standards Update and Change in Accounting Principle [Abstract]
Warrants 2020.
Warrants2020 [Member]
2020 Warrants
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Expected vesting period for non-vested share-based compensation
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Accrued expenses
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Chief Executive Officer [Member]
Dr. Tabuteau
Cash Equivalents, at Carrying Value [Abstract]
Cash Equivalents
Long-term Debt [Text Block]
Loan and Security Agreement
Change in accounting principle, accounting standards update, adoption date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Subsequent Events [Abstract]
Subsequent Event [Line Items]
Statement [Table]
Statement [Table]
Operating Lease, Weighted Average Remaining Lease Term
Operating lease, remaining lease term
Represents the information if the outstanding principle and advances under loan agreement exceeds fifty five million.
Outstanding Advances Under Loan Agreement Equals Or Exceeds Fifty Five Million [Member]
Outstanding principle and advances under the loans agreement exceeds 55 million
Entity File Number
Entity File Number
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Segment Reporting, Disclosure of Entity's Reportable Segments [Abstract]
Segment and Geographic Information
Tax Year 2017 [Member]
Tax Year 2017
Increase (Decrease) in Other Noncurrent Assets
Other assets
Retained Earnings [Member]
Accumulated Deficit
Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Accounting Standards Update [Domain]
Accounting Standards Update [Axis]
Payments of Stock Issuance Costs
Issuance costs
Represents common warrants.
Common Warrants [Member]
Common warrants
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Net federal operating loss carryforward
An underwritten sale of stock.
Underwritten Public Offering [Member]
Underwritten Public Offering
Liabilities, Current [Abstract]
Current liabilities:
Subsequent Event
Earnings Per Share, Basic and Diluted [Abstract]
Basic and diluted net loss per common share:
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Aggregate intrinsic value, Exercisable
Operating Lease, Liability
Present value of operating lease liabilities
Total operating lease liabilities
Common Stock [Member]
Common Stock
Director [Member]
Director
Entity Public Float
Entity Public Float
Cover [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted average grant date fair value, Outstanding, ending balance
Weighted average grant date fair value, Outstanding, beginning balance
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credits
Represents the prepayment of debt occurring on or after the first anniversary and prior to the second anniversary of the Closing Date.
Debt Instrument Prepayment Occurs On Or After First Anniversary And Prior To Second Anniversary Of Closing Date [Member]
Prepayment Occurs on or After First Anniversary and Prior to Second Anniversary of the Closing Date
Statement of Stockholders' Equity [Abstract]
Number of Operating Segments
Number of operating segments
Increase (Decrease) in Other Accounts Payable and Accrued Liabilities
Accrued expenses and other current liabilities
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value of Financial Instruments
Change in operating lease liability.
Change In Operating Lease Liability
Change in operating lease liability
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units
Restricted Stock Units
Document Transition Report
Document Transition Report
Represents about term loan tranche five.
Term Loan2020 Tranche Five [Member]
Term loan 2020 tranche five
Disclosure of accounting policy for significant risks and uncertainties.
Significant Risks And Uncertainties Policy Policy [Text Block]
Significant Risks and Uncertainties
Deferred Tax Assets, Property, Plant and Equipment
Fixed Assets
Proceeds from Stock Options Exercised
Proceeds from issuance of common stock upon exercise of options
Research and Development Expense
Research and development
Research and development expense recognized
Research and Development Expense, Total
Recent Accounting Pronouncements
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Information pertaining to 2014 warrants.
Warrants2014 [Member]
2014 Warrants
Share-based Payment Arrangement, Expense
Stock-based compensation expense
Warrants issued during period debt financing.
Warrants Issued During Period Debt Financing
Issuance of warrants upon debt financing
2020-10
Accounting Standards Update 2020-10 [Member]
Number of warrants (or share units) issued during the current period.
Warrants Issued In Period
Issued
Statement of Financial Position [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Dividend yield
Number of shares, Released
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of shares, Released
Share based compensation arrangement by share based payment award equity instruments other than options cancelled in period.
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Cancelled In Period
Stock option to purchase shares of common stock cancelled
Number of shares, Cancelled
Two thousand thirteen equity compensation plan.
Two Thousand Thirteen Equity Compensation Plan [Member]
2013 Plan
Operating Lease, Right-of-Use Asset, Amortization Expense
Amortization of operating lease right-of-use asset
Represents the consecutive number of trading days to determine the weighted average price per share of ordinary shares.
Consecutive Trading Days
Prior trading days
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
U.S. federal statutory income tax rate
The amount utilized for warrants.
Warrant Utilized
Warrant utilized
Stockholders' Equity Attributable to Parent [Abstract]
Stockholders’ equity:
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Weighted average contractual term
Period of time, after the first commercial sale of the applicable product, the license agreement is valid, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
License Agreement Term
License agreement term, from first commercial sale
Warrants and Rights Note Disclosure [Abstract]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Computation of Basic and Diluted Net Loss per Common Share
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted average exercise price, Exercised
2025
Long-Term Debt, Maturity, Year Four
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
2024
Lessee, Operating Lease, Liability, to be Paid, Year Three
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Represents the prepayment of debt occurring after the second anniversary and prior to the third anniversary of the Closing Date.
Debt Instrument Prepayment Occurs On Or After Second Anniversary And Prior To Third Anniversary Of Closing Date [Member]
Prepayment Occurs on or After Second Anniversary and Prior to Third Anniversary of Closing Date
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Payment Arrangement, Percent
Stock based compensation - Excess tax benefit
Award Type [Axis]
Award Type
Entity Shell Company
Entity Shell Company
Liabilities and Equity [Abstract]
Liabilities and stockholders’ equity
Two thousand eighteen registered direct offering.
Two Thousand Eighteen Registered Direct Offering [Member]
2018 Registered Direct Offering
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Represents information pertaining to tranche one of convertible notes payable.
Convertible Notes Payable Tranche One [Member]
September 2014 Notes
Earnings Per Share [Text Block]
Net Loss per Common Share
Represents about term loan tranche four.
Term Loan2020 Tranche Four [Member]
Term loan 2020 tranche four
Counterparty Name [Domain]
Counterparty Name
Represents the prepayment penalty percentage on principal amount of debt.
Debt Instrument Prepayment Penalty Percentage
Percentage of prepayment penalty
The minimum amount of cash should be maintained as first priority security interest under the terms of debt instrument.
Long Term Debt Additional Drawn Covenant Minimum Cash As Security Interest
Minimum cash to be maintain as a first priority security interest
Deferred Tax Liabilities, Leasing Arrangements
Lease Asset
Schedule of operating lease.
Schedule Of Operating Lease Table [Text Block]
Summary of Presentation of Operating Leases
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of shares
Amendment Flag
Amendment Flag
Product and Service [Axis]
Product and Service
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Title of Individual [Domain]
Title of Individual
This member stands for Term Loan 2019.
Term Loan2019 [Member]
2019 Term Loan
Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized compensation cost related to non-vested stock options expected to be recognized
Long-term Debt
Outstanding amount
Long-term Debt, Total
Subsequent Events
Subsequent Events [Text Block]
Amortization of Debt Discount (Premium)
Amortization of debt discount
This member stands for 2019 Term loan Tranche Two.
Term Loan2019 Tranche Two [Member]
Term Loan 2019, Tranche Two
Tax Period [Domain]
Tax Period
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Other Assets, Noncurrent
Other assets
Other Assets, Noncurrent, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Intrinsic value of stock options exercised
Sale of Stock [Axis]
Sale of Stock
Number of shares of stock issued as a result of the exercise of warrants.
Stock Issued During Period Shares Stock Warrants Exercised
Exercise of warrants (in shares)
Line of Credit Facility [Table]
Line Of Credit Facility [Table]
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Compensation cost not yet recognized related to unvested RSUs
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock upon financing, net