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<!--Created on: 11/9/2018 3:20:48 PM-->
<!--Modified on: 11/9/2018 3:20:48 PM-->
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  <xsd:element name="DebtInstrumentPrepaymentPremiumPercentOfOustandingPrincipalConditionThree" id="axsm_DebtInstrumentPrepaymentPremiumPercentOfOustandingPrincipalConditionThree" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="DebtInstrumentPrepaymentPremiumConditionOneTerm" id="axsm_DebtInstrumentPrepaymentPremiumConditionOneTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LongTermDebtNetNoncurrentDebtDiscount" id="axsm_LongTermDebtNetNoncurrentDebtDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="LongTermDebtCurrentNetOfNoncurrentDebtDiscount" id="axsm_LongTermDebtCurrentNetOfNoncurrentDebtDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="ShelfRegistrationStatementMaximumAggregateAmountIssuable" id="axsm_ShelfRegistrationStatementMaximumAggregateAmountIssuable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="WarrantsOutstandingRollForward" id="axsm_WarrantsOutstandingRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantsExercisedInPeriod" id="axsm_WarrantsExercisedInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantsOutstandingWeightedAverageExercisePriceRollForward" id="axsm_WarrantsOutstandingWeightedAverageExercisePriceRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantsExercisedInPeriodWeightedAverageExercisePrice" id="axsm_WarrantsExercisedInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <element id="axsm_CommonStockSalesAgreementAuthorizedAmount" name="CommonStockSalesAgreementAuthorizedAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="CommonStockSalesAgreementCommissionPercentage" id="axsm_CommonStockSalesAgreementCommissionPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="CommonStockSalesAgreementGrossSales" id="axsm_CommonStockSalesAgreementGrossSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element id="axsm_WarrantsIssuedInPeriod" name="WarrantsIssuedInPeriod" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="CommonWarrantsMember" id="axsm_CommonWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PlacementAgentWarrantsMember" id="axsm_PlacementAgentWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FairValueOfWarrants" id="axsm_FairValueOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="WarrantLiability" id="axsm_WarrantLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="WarrantExercisePrice" id="axsm_WarrantExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="SharePriceChangeTenPercentIncreaseMember" id="axsm_SharePriceChangeTenPercentIncreaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SharePriceChangeTenPercentDecreaseMember" id="axsm_SharePriceChangeTenPercentDecreaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ExpectedVolatilityChangeTenPercentIncreaseMember" id="axsm_ExpectedVolatilityChangeTenPercentIncreaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ExpectedVolatilityChangeTenPercentDecreaseMember" id="axsm_ExpectedVolatilityChangeTenPercentDecreaseMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="WarrantLiabilityIncreaseDecrease" id="axsm_WarrantLiabilityIncreaseDecrease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <element id="axsm_StockIssuedDuringPeriodValueNewIssuesNet" name="StockIssuedDuringPeriodValueNewIssuesNet" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="axsm_CommonStockSalesAgreementNetSales" name="CommonStockSalesAgreementNetSales" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>
