<?xml version="1.0" encoding="US-ASCII"?>
<!-- DFIN New ActiveDisclosure (SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date :2026-04-24T16:59:43.3793+00:00 -->
<!-- Copyright (c) 2026 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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        <link:definition>75000 - Document - Cover</link:definition>
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          <link:loc xlink:type="locator" xlink:href="axsm-20260424.xsd#axsm_ForAwardsThatAreGrantedAndVestInSameYearFairValueAsOfVestingDateMember" xlink:label="axsm_ForAwardsThatAreGrantedAndVestInSameYearFairValueAsOfVestingDateMember"/>
          <link:loc xlink:type="locator" xlink:href="axsm-20260424.xsd#axsm_DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember" xlink:label="axsm_DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract" xlink:label="dei_CoverAbstract"/>
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          <link:loc xlink:type="locator" xlink:href="axsm-20260424.xsd#axsm_ForAwardsGrantedInPriorYearsThatVestInFiscalYearChangeInFairValueFromEndOfPriorFiscalYearToVestingDateMember" xlink:label="axsm_ForAwardsGrantedInPriorYearsThatVestInFiscalYearChangeInFairValueFromEndOfPriorFiscalYearToVestingDateMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName"/>
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          <link:loc xlink:type="locator" xlink:href="axsm-20260424.xsd#axsm_DeductionForAmountsReportedUnderStockAwardsAndOptionAwardsColumnsInSummaryCompensationTableForApplicableFiscalYearMember" xlink:label="axsm_DeductionForAmountsReportedUnderStockAwardsAndOptionAwardsColumnsInSummaryCompensationTableForApplicableFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="axsm-20260424.xsd#axsm_YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearMember" xlink:label="axsm_YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearMember"/>
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          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value from last day of prior year to vesting date of unvested equity awards that vested during year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_AddBackYearEndFairValueOfAnyEquityAwardsGrantedDuringCoveredFiscalYearThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Add Back Year-end Fair Value of Any Equity Awards Granted During Covered Fiscal Year That Are Outstanding and Unvested as of End of Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_AddBackYearEndFairValueOfAnyEquityAwardsGrantedDuringCoveredFiscalYearThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Add back year-end fair value of any equity awards granted during covered fiscal year that are outstanding and unvested as of end of fiscal year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_AddBackYearEndFairValueOfAnyEquityAwardsGrantedDuringCoveredFiscalYearThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Add Back: The Year-end Fair Value of Any Equity Awards Granted During the Covered Fiscal Year That Are Outstanding and Unvested as of the End of the Fiscal Year</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_VestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_VestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Vesting-date fair value of equity awards granted during year that vested during year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_FairValueAtLastDayOfPriorYearOfEquityAwardsFailedToMeetVestingConditionsDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value At Last Day Of Prior Year Of Equity Awards Failed To Meet Vesting Conditions During Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_FairValueAtLastDayOfPriorYearOfEquityAwardsFailedToMeetVestingConditionsDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value at last day of prior year of equity awards failed to meet vesting conditions during year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_FairValueAtLastDayOfPriorYearOfEquityAwardsFailedToMeetVestingConditionsDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value At Last Day Of Prior Year Of Equity Awards Failed To Meet Vesting Conditions During Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_Nonpeoname_lbl" xlink:role="http://www.xbrl.org/2003/role/label">NonPEOName</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_Nonpeoname_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Non Peo Name.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_Nonpeoname_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Non PEO Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_AggregateEquityAwardAdjustmentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Aggregate Equity Award Adjustments [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_AggregateEquityAwardAdjustmentsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Aggregate equity award adjustments.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ForAwardsThatAreGrantedAndVestInSameYearFairValueAsOfVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">For Awards That Are Granted and Vest in Same Year, Fair Value As of Vesting Date [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ForAwardsThatAreGrantedAndVestInSameYearFairValueAsOfVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">For awards that are granted and vest in same year, fair value as of vesting date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ForAwardsThatAreGrantedAndVestInSameYearFairValueAsOfVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">For Awards That Are Granted and Vest in the Same Year, the Fair Value as of the Vesting Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Dollar Value Of Any Dividends Or Other Earnings Paid On Stock Or Option Awards During Year Prior To The Vesting Date That Are Not Otherwise Included In The Total Compensation During Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Dollar value of any dividends or other earnings paid on stock or option awards during year prior to the vesting date that are not otherwise included in the total compensation during year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Dollar Value Of Any Dividends Or Other Earnings Paid On Stock Or Option Awards During Year Prior To The Vesting Date That Are Not Otherwise Included In The Total Compensation During Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CoverAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ChangeInFairValueOfAnyAwardsGrantedInPriorYearsThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Fair Value of Any Awards Granted in Prior Years That Are Outstanding and Unvested as of End of Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ChangeInFairValueOfAnyAwardsGrantedInPriorYearsThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of any awards granted in prior years that are outstanding and unvested as of end of fiscal year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ChangeInFairValueOfAnyAwardsGrantedInPriorYearsThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">The Change in Fair Value of Any Awards Granted in Prior Years That Are Outstanding and Unvested as of the End of the Fiscal Year</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_AggregateEquityAwardsAdjustmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Aggregate Equity Awards Adjustment [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_AggregateEquityAwardsAdjustmentMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Aggregate equity awards adjustment.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ForAwardsGrantedInPriorYearsThatVestInFiscalYearChangeInFairValueFromEndOfPriorFiscalYearToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">For Awards Granted in Prior Years That Vest in Fiscal Year, Change in Fair Value from End of Prior Fiscal Year to Vesting Date [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ForAwardsGrantedInPriorYearsThatVestInFiscalYearChangeInFairValueFromEndOfPriorFiscalYearToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">For awards granted in prior years that vest in fiscal year, change in fair value from end of prior fiscal year to vesting date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ForAwardsGrantedInPriorYearsThatVestInFiscalYearChangeInFairValueFromEndOfPriorFiscalYearToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">For Awards Granted in Prior Years That Vest in the Fiscal Year, the Change in the Fair Value from the End of the Prior Fiscal Year to the Vesting Date</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ReportedValueOfEquityAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Reported Value Of Equity Awards [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_ReportedValueOfEquityAwardsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Reported Value Of Equity Awards [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_DeductionForAmountsReportedUnderStockAwardsAndOptionAwardsColumnsInSummaryCompensationTableForApplicableFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Deduction for Amounts Reported under Stock Awards and Option Awards Columns in Summary Compensation Table for Applicable Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_DeductionForAmountsReportedUnderStockAwardsAndOptionAwardsColumnsInSummaryCompensationTableForApplicableFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Deduction for amounts reported under stock awards and option awards columns in summary compensation table for applicable fiscal year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_DeductionForAmountsReportedUnderStockAwardsAndOptionAwardsColumnsInSummaryCompensationTableForApplicableFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deduction for Amounts Reported under Stock Awards and Option Awards Columns in Summary Compensation Table for Applicable Fiscal Year</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="axsm_YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Year-end fair value of equity awards granted during year that remained unvested as of last day of year.</link:label>
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          <link:definitionArc xlink:type="arc" order="10" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="axsm_ChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="11" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="axsm_FairValueAtLastDayOfPriorYearOfEquityAwardsFailedToMeetVestingConditionsDuringYearMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="12" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="axsm_DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="13" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="axsm_AggregateEquityAwardsAdjustmentMember" priority="2" use="optional"/>
        </link:definitionLink>
      </link:linkbase>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="axsm_VestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearMember" name="VestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_ChangeInFairValueOfAnyAwardsGrantedInPriorYearsThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember" name="ChangeInFairValueOfAnyAwardsGrantedInPriorYearsThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_ForAwardsThatAreGrantedAndVestInSameYearFairValueAsOfVestingDateMember" name="ForAwardsThatAreGrantedAndVestInSameYearFairValueAsOfVestingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_ForAwardsGrantedInPriorYearsThatVestInFiscalYearChangeInFairValueFromEndOfPriorFiscalYearToVestingDateMember" name="ForAwardsGrantedInPriorYearsThatVestInFiscalYearChangeInFairValueFromEndOfPriorFiscalYearToVestingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_AddBackYearEndFairValueOfAnyEquityAwardsGrantedDuringCoveredFiscalYearThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember" name="AddBackYearEndFairValueOfAnyEquityAwardsGrantedDuringCoveredFiscalYearThatAreOutstandingAndUnvestedAsOfEndOfFiscalYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_AggregateEquityAwardAdjustmentsMember" name="AggregateEquityAwardAdjustmentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_ChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsMember" name="ChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_DeductionForAmountsReportedUnderStockAwardsAndOptionAwardsColumnsInSummaryCompensationTableForApplicableFiscalYearMember" name="DeductionForAmountsReportedUnderStockAwardsAndOptionAwardsColumnsInSummaryCompensationTableForApplicableFiscalYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_Nonpeoname" name="Nonpeoname" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="axsm_AggregateEquityAwardsAdjustmentMember" name="AggregateEquityAwardsAdjustmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember" name="DollarValueOfAnyDividendsOrOtherEarningsPaidOnStockOrOptionAwardsDuringYearPriorToTheVestingDateThatAreNotOtherwiseIncludedInTheTotalCompensationDuringYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearMember" name="YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_FairValueAtLastDayOfPriorYearOfEquityAwardsFailedToMeetVestingConditionsDuringYearMember" name="FairValueAtLastDayOfPriorYearOfEquityAwardsFailedToMeetVestingConditionsDuringYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_ChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearMember" name="ChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="axsm_ReportedValueOfEquityAwardsMember" name="ReportedValueOfEquityAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
</xsd:schema>
